Catalytic Asymmetric Radical Reactions

Strategies to develop catalytic asymmetric radical reactions, from metal-based methods to organocatalytic systems

Catalytic Asymmetric Radical Reactions systematically and comprehensively summarizes the development of different strategies to realize asymmetric radical reactions, from metal-based methods to organocatalytic systems.

The book starts with the background introduction of this topic and emphasizes the significance and challenge of the stereocontrol over the radical intermediates. Subsequently, it describes the detailed strategies to realize the asymmetric radical reactions, demonstrating how the design of chiral catalysts and substrates helps to achieve the asymmetric induction. Finally, it summarizes the developed strategies and presents a perspective in future development of asymmetric radical reactions.

Catalytic Asymmetric Radical Reactions includes information on:

• Earth-abundant transition metal (e.g., iron, cobalt, nickel, copper, and manganese)-catalyzed asymmetric radical reactions
• Photoredox/earth-abundant metal-catalyzed asymmetric radical reactions and precious transition metal-catalyzed asymmetric radical reactions
• Chiral Lewis acid-catalyzed asymmetric radical transformations and chiral-at-metal complex-catalyzed asymmetric radical reactions
• Organocatalysis via covalent bonds and hydrogen bonding for asymmetric radical transformations
• Covalent interaction (S/Sn/B-centered radical)-induced asymmetric radical reactions

Catalytic Asymmetric Radical Reactions is a timely reference for researchers in academia and industry working in the fields of organic synthesis, drug discovery, and materials science.